Frankie, "cursed" from their brain's past life, gets help from Clawdeen and Draculaura to break it.

On her birthday, monster expert Clawdeen receives her mother's necklace from her father. It guides her to a hidden school called Monster High.

Clawdeen is worried that she will permanently turn back into human when the full moon hits. She gets tricked into going passed the school's veil when she had some consultation from the local werewolf students Romulus and Barkimedes. Now, Clawdeen must find a way to save Cleo and herself from being seen by monster hunters, by embracing her human side.

It's Picture Day at Monster High, and Frankie is panicking about getting their picture taken. In a fit of anxiety, they accidentally zap the school camera, sending it on a rampage as it sucks up every monster in sight. Frankie is the only monster left and they must save everyone from the menace of the camera.

Draculaura and Toralei compete for Head Fearleader of the Fearleading Squad. However, Toralei knows Draculaura is a witch and threatens to expose her secret unless Draculaura drops out, with Lagoona tagging along with Toralei. In order to stop Toralei, Clawdeen and Frankie help Draculaura cast a spell on her, but not before Draculaura learns that Lagoona has a secret of her own and she cannot let Toralei expose Lagoona's secret as well.

Clawdeen keeps shedding her werewolf hair and must figure out how to stop shedding. Then, she meets Romulus and Barkimedes again and she also meets a new member of the werewolf pack named Howleen. At first, Clawdeen is not interested in joining the pack after that previous prank from the werewolf boys, but then she changes her mind and must pass the tests on joining the pack. However, Clawdeen has a choice to make: Clawdeen has to help Draculaura and Frankie pass their presentation assignments or she will ditch them and join the werewolf pack. When Clawdeen chooses the latter, she soon realizes that it is another prank made by the werewolf boys and they want to steal her pendant on a full moon.

Deuce participates in a fundraiser by selling rock candy and collect enough money in order to win a trophy like his mom did. Clawdeen, Frankie, and Draculaura have decided to help him make more rock candies to sell, but the ghouls are overworked and took a break. To make things worse, Deuce's snakes used him to make even more rock candies and forced him to accidentally turn the other students into rock candy statues. Now, he must find a way to turn them back to normal with the help of the ghouls, even if it means giving up the fundraiser.

Clawdeen visits his father at her own house for a weekend while maintaining her human side. But soon after, Clawdeen reveals her werewolf side to him, which he knew she is half-werewolf all along, though he doesn't know what happened to Clawdeen's mom, who was pure werewolf, after they got married and she mysteriously vanished. Meanwhile, Cleo was desperate into getting more views that will surpass Draculaura's views. She then escapes from Clawdeen's house to meet the humans in hopes to earn a lot of views. Clawdeen must stop her from being revealed as a monster in front of the humans before the ghouls get in trouble.

Clawdeen and her father discover a book from Monster High that may be a clue about her mom's disappearance. Clawdeen, Frankie, and Draculaura go to a library and find a book that was overdue a decade ago. They then discover a puzzle that opens the gate where Clawdeen's necklace must be inserted. However, an unknown creature was unleashed and stole Clawdeen's pendant. To stop the Splitzies from destroying Monster High, the Wolf siblings sing a lullaby and put them all to a machine that will merge them back together. Headless Headmistress Bloodgood warns that opening the gate that's not on the blood moon eclipse will destroy not only Monster High, but the entire world. The monsters enjoy their time of their own at Monster High.

Draculaura plans to celebrate "Nightmore", a Holiday for monsters to have fun, but her witchcraft is disabled. She invites Clawdeen, Clawd, Frankie, Lagoona, and Heath to celebrate at an abandoned mansion where there is snow. When Clawdeen steps outside, she is buried in the snow and they all encounter a Yeti girl named Abbey Bominadle. Abbey explains her story and the monsters decide that she should celebrate Nightmore with them, which Draculaura accepts. Abbey's mom attacks Monster High and Draculaura, Abbey, and the rest are on the road back to Monster High. After leaving the mountains, Draculaura and the rest convince Bloodgood to let all Yeti kind in at Monster High, and they celebrate Nighmore at Monster High in a song written by Draculaura.

Draculaura is paired up with Clawd for the Monster High Dance-Off, and they need to follow the scroll's dancing steps to win the dance-off like the Boogeyman did. However, it may have been a bad idea for Draculaura, for her vampness level keeps lowering every time she is being laughed at by Toralei and everyone else, which causes her to decompose. In order to stop decomposing and raise her vampness level high enough, she has to get Clawd to wear the enchanted dancing shoes in order to dance better. But suddenly, the shoes can't stop him from dancing, so Draculaura, Frankie, and Clawdeen must help him in order to stop dancing.

Cleo is hoping that she will get her lead role for the upcoming school play, but her sister, Nefera, came back from her trip to Scaris for a visit. Seeing that she doesn't want Nefera to take the lead role away from her like she did in the past, Cleo must go inside her family's ancient tomb and grab the Heart of Cleopatra necklace. While Clawdeen distracts Nefera, Cleo and Frankie went inside the ancient tomb. Suddenly, Frankie was kicked out because only the De Nile family may step into the tomb. Upon grabbing the necklace, however, Cleo activated a booby trap and put Nefera in danger. Now, Cleo must make a sacrifice in order to shut off the booby trap and save her own sister.

While building a robot, Frankie and Watzie witnessed a calendar with the dragons picture, and Frankie noticed Watzie's dragon tail wiggling. Headless Headmistress Bloodgood explained to Frankie that it's the dragon migration, and all dragons must go to their natural habitat in order to migrate. However, Frankie doesn't want to let Watzie go, despite the fact that Watzie is part dragon. With the help of their ghoul friends, they are going to do everything they can in order to make him stay with them. Unfortunately, he is not satisfied with any of those activities. With no other choice, Frankie let him go so he can migrate with his fellow dragons for a long time.

Draculaura, Frankie, and Clawdeen came back from their school break, but they haven't done their homework for a while. And what's worse for Draculaura is that Count Fabulous, a little bat with manners, is babysitting her because he treats her like a "baby bloodsucker". Clawdeen then shows her a witchcraft codex that can only be opened by true witches with their familiar. The ghouls must find Draculaura's familiar, a cat, so they can open the book for her to cast a spell that will help them finish their homework before the deadline. However, if they don't find her familiar in time, the book will self-destruct and Draculaura may never cast a spell like a true witch again.

The tryouts for the Fearleading Squad has ended, and the following students were selected: Clawdeen, Clawd, Iris, and Kuma. Unfortunately, Frankie were not chosen for the Fearleading Squad, which makes them disappointed. Then, they followed Heath's advice to "bottle up their feelings", and they did, literally with their lightning in a bottle. But, during the Fearleading Squad showcase, Frankie tried to bottle up their feelings again until they accidentally cause a blackout. Now, they must follow Cleo's advice to let go of their feelings by crying their eyes out, and it worked. Now that they are calm enough, Frankie must save the Fearleading Squad showcase.

After his reunion with his dad, Clawd got an urgent phone call from Clawdeen and he met her in a secret hideout, which turns out that it's play time in the catacombs with Frankie, Draculaura, Lagoona, and Deuce. During their games, Clawd became overprotective with Clawdeen by trying to keep her safe, which irritates her. As they are playing a game of "Hide n Shriek", the Wolf siblings fell down to a trap where the Flying Venus Trap lives there. After many failed attempts, Clawdeen is fed up with Clawd overprotecting her just because he is technically one year older than her. However, they made amends with each other and found a way to get out of the Flying Venus Trap room to reunite with their friends.

Cleo becomes obsessed with a newly-installed app called "Horoscare" when she believes that her jewel idol, Pearl Ryuzaki, will arrive at Monster High. She gets Frankie to help her make a welcome party for Pearl, and they are starting to develop feelings for each other. Meanwhile, Toralei believes from the Horoscare that the humans might arrive, so she sets up a trap in front of Monster High. After making their final preparations for the welcome party, Cleo and Frankie stepped outside to welcome Pearl. But, they will have to get through Toralei and avoid her traps. Upon opening the gates, however, it may not be what Cleo is hoping for.

Ghoulia is excited when her idol, Skelly Vonderbone, arrives at the auditorium to practice with the Boo Crew for their performance. However, when she was about to sing in front of Skelly, Ghoulia gets a case of "brain freeze", a symptom where zombies yell "brains" for whatever reason, and was humiliated. Frankie and Lagoona have decided to help Ghoulia conquer her fear, but it wasn't enough for Ghoulia to stop yelling "brains". When Ghoulia is about to quit, Skelly gives her a useful advice (or rather a secret code for her DDR video game) on how to conquer her fear by embracing her heart out, right before Ghoulia and the rest of the Boo Crew get to perform with Skelly.

Draculaura, Clawdeen, and Frankie are having trouble eating lunch at the table that was broken down. They tried to sit at the new lunch table, but Toralei beat them to it. The Boo Crew and Toralei made a bet that the Boo Crew must have a sleepover at the library, and if they leave before nightfall, Toralei wins. Later, they meet Twyla, an autistic boogey monster who hates loud noises, who shows Clawdeen a book that may be related to her moonclaw. But, Toralei watches from behind and tries to sabotage the sleepover with a stinkworm, which turns out to be a bookworm that eats books and grows. Now, the Boo Crew and Twyla must find a way to get rid of the bookworm.

It's the scare-itage event at Monster High, and Frankie witnessed Kuma's scare-itage as he demonstrated what do the Onikumas do, such as lifting giant rocks. After the event, Frankie was interested and they would like to know more about the Onikumas. Kuma then explained to them about the Onikuma ritual, and as he left, Frankie have decided that they should do the ritual in order to surprise him. However, after the ritual was done, Frankie sees Ghoulia, Draculaura, Spectra, and the rest being possessed like zombies and causing havoc at Monster High. When Kuma returned, Frankie explained the mistake they made and they must find a way to turn the Boo Crew back to normal while Lagoona holds them off.

Lagoona wanted to make a movie based on her real life, so she becomes a director for her movie with Draculaura playing as her and Deuce playing as the love of her life. However, the Boo Crew are requesting to make some changes for her movie, making Lagoona bite some of the furniture out of anger. After finishing the movie, Twyla talked to Lagoona about how she is feeling, which Lagoona explained that she has a case of the chomps, where her family once had an argument with each other and started chomping things. Now that she felt better thanks to Twyla, Lagoona must stand up to herself and fix her movie without chomping.

Toralei is feeling jealous that nobody in Monster High wants to sit next to her during lunchtime. When she looked at the flier with all kinds of worms, Toralei became interested in the earworms and she has a devious plan to make the monsters like her. She and her cousins, Purrsephone and Meowlody, form a band called "The Hissfits" and performed a song while releasing the earworms Toralei stole to possess them and force them to like Toralei, which her cousins are feeling like she is using them. Things go awry, however, as Toralei is trying to get away from the possessed monsters who love her too much. With no other choice, she gets help from the Wolf siblings in order to remove the earworms.